Formulation and Evaluation of Paracetamol Tablets using Coconut Oil as a Binder

Abstract

Tablets are the medicament with suitable excipients. It comprises a mixture of active substances and excipients, usually pressed or compacted from a powder into a solid dose. The aim of this study was to formulate paracetamol tablets using Coconut oil as a binder in different concentrations (1%, 2%, 3%) and evaluate them with basic parameters. The granules manufactured using the binder had good flow property and compressibility. There are various examples of binders that can be used for tablet formulation. Here the efforts were made to formulate the paracetamol tablets by using coconut oil to check whether the tablet can be formulated and the other evaluation parameters for tablets, thereafter. Using coconut oil as a binder in the end gave satisfactory result as we could formulate a tablet with effective concentration of coconut oil with 1%.Theformulated tablets thereafter were evaluated for the characterization for granules to check such as flow property, bulk density, tap density etc.as well as the tablets were also evaluated for disintegration and dissolution as well.
 Keywords: Paracetamol, Binder, Dry granulation, Excipients, Direct compression, Disintegration, Dissolution