Formulation and evaluation of oxymetazoline hydrochloride nasal gels

Abstract

The main intend of the implement sniff out formulate and evaluate oxymetazoline nasal gels. To achieve more persistent blood levels with decrease dosage of medicine by extended drug evidence and by passing hepatic initially cross metabolism and body including inferable disgrace. Mod FTIR & DSC spectra there is not any discrepancein the seam clean medicine, polymers & lipids. The Carbopol consisting of reinforce precail eventual scintillating moreover transparent Poloxamer, Hydroxy Propyl Methyl cellulose gels crop up prospective lucent as a consequence frosted slimy. The pH value of all developed formulations of gels (ONGF1-ONGF8) was in the range of 6.2 to 6.9. Spreadability of gels was in the range 19.51 - 33.91 g.cm/sec, The Viscosity of various formulated gels was found in range of 8628 to 9622 centipoises. The percentage drug content of all prepared gel formulations were found to be in the range of 78.53 to 98.56 %. The gel strength of all prepared formulations of gels was found to be in the range of 69 to 96 %. In-vitro diffusion drug release of Oxymetazoline Hydrochloride of nasal gels ONGF1 shows the 95% drug release. The release order kinetics shows all the formulations ONGF1 to ONGF8 formulations were followed Korsemeyer-Peppas with correlation coefficient R2=0.8969 & 0.2692 respectively. ONGF1 formulation follows both Zero order and Korsmeyer-Peppas models, it indicates diffusion release mechanism followed by non-fickian transport.
 Keywords: Nasal, gels, Oxymetazoline, In vitro diffusion, Carbopol.