Abstract
The aim of this work is to apply factorial design methods to reduce the number and time of the various steps required to formulate and evaluate stable emulsions. A preliminary study was performed to optimize the most accurate operating parameters. These operating conditions were applied to the determination of the required HLB of o/w emulsion. A second experimental design was then applied and emulsion stability was estimated by the average size of the droplets, the emulsion viscosity and the emulsion conductivity. In the case of average diameter, the best emulsion corresponds to the smallest particle size. For viscosity, a method is suggested to determine the required HLB. For conductivity, a graphic method was used. Experimental design allowed us to determine the required HLB with good approximation in five runs for the average diameter and viscosity studies while the conductivity study needed at least eight runs and confirmed the results obtained with the first two methods.
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