Abstract
Objective: In this study, a polysaccharide isolated from the seeds of Cajanus cajan (pigeon pea) was investigated as a super disintegrant in the orodispersible tablets of diclofenac sodium.
 Methods: Diclofenac sodium tablets were prepared separately using different concentrations (5%, 7.5%, 10%, and 15% w/w) of isolated Cajanus cajan seed polysaccharide (natural) and sodium starch glycolate (synthetic) as super disintegrant by the direct compression method. Evaluation of tablets was done for various pre-and post-compression parameters. The stability studies were performed on optimized formulation F5. The disintegration time and in vitro drug release of the formulation F5 was compared with pregelatinized starch and synthetic super disintegrant (sodium starch glycolate).
 Results: The drug-excipient interactions were characterized by Fourier transform infrared studies. The Optimized formulation F5 containing 15% polysaccharide showed wetting time of 118.7 seconds with 105.3 seconds of disintegration time and 95.61% dissolved in 3 min.
 Conclusion: The present work revealed that Cajanus cajan seed polysaccharide has a good disintegrating agent in the formulation of orodispersible tablets.
Highlights
Orodispersible tablets (ODTs) are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on a tongue
FTIR spectrum of pure diclofenac sodium by KBr pellet method was shown in fig
The FTIR of the pure drug was characterized peak at around 1602.85 cm-1 C=C and COOH-Carboxylic acid group stretching at 3203.76 cm-1and N-H group stretching at 3387.00 cm-1were observed
Summary
Orodispersible tablets (ODTs) are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on a tongue. The technologies utilized for the preparation of ODTs include lyophilization, direct compression, moulding, cotton candy process, spray drying, sublimation, mass extraction, and quick dissolving film formation. These techniques are based upon the principles of increasing porosity and the addition of super disintegrants and water soluble excipients in the tablets [2,3,4]. Natural polymers are ubiquitous material in the plant world and most useful to humans as food preparations, binding agent, disintegrating agent, and thickener [5] They act as vehicles which transport the incorporated drug to the site of absorption and are expected to guarantee the stability of the incorporated drug, the precision, and accuracy of the dosage, and improve the organoleptic properties of the drugs [6]. These changes may be achieved by altering starch properties such as pasting temperature, viscosity, surface charge and hydrophilic/hydrophobic nature [7]
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