Abstract
Different formulations for the treatment of eye infections are usually administered in the form of conventional ocular drug delivery systems which are topical eye drops or ointments (1). Typically ophthalmic bioavailabilities of only 1–10% are achieved due to the short precorneal residence time of ophthalmic solutions. (2) The preparation and evaluation of gel containing antibiotic azithromycin combined with different polymers like Carbopol, sodium alginate and Hydroxypropyl cellulose (HPC) was done and assessed to find out which polymer could best be used in preparing ophthalmic gels for this antibiotic using factorial design. Since the efficacy of these gels is dependent on factors like viscosity and pH, the polymers in these gels were also examined for different parameters such as pH, in vitro release, permeation and microbiological evaluation.
Highlights
Several ophthalmic problems have been investigated including bacterial conjunctivitis, blepharitis and keratitis, and topical antibiotics have been used in the treatment of these problems
(2) The preparation and evaluation of gel containing antibiotic azithromycin combined with different polymers like Carbopol, sodium alginate and Hydroxypropyl cellulose (HPC) was done and assessed to find out which polymer could best be used in preparing ophthalmic gels for this antibiotic using factorial design
The preparation and evaluation of gel containing antibiotic azithromycin combined with different polymers like Carbopol, sodium alginate and Hydroxypropyl cellulose (HPC) was done and assessed to find which polymer couldbest be used in preparing ophthalmic gels for this antibiotic using factorial design
Summary
Several ophthalmic problems have been investigated including bacterial conjunctivitis, blepharitis and keratitis, and topical antibiotics have been used in the treatment of these problems. Different formulations for treatment of eye infections are usually administered in the form of conventional ocular drug delivery systems which are topical eye drops or ointments (1). Eye drops and suspensions are often used for topical administration of ophthalmic active drug to tissue around ocular cavity. The limitation of the conventional liquid ophthalmic formulations is that they demonstrate low bioavailability because of constant lacrimal drainage in the eye. The normal drainage of an instilled drug dose commences immediately upon instillation and is essentially completed within 5 min.Typically ophthalmic bioavailabilities of only 1–10% are achieved due to the short precorneal residence time of ophthalmic solutions. The use of gels for ocular administration of drug offers many advantages compared to conventional ocular drug delivery systems like eye drops which leads to prolonged corneal contact time. The use of gels for ocular administration of drug offers many advantages compared to conventional ocular drug delivery systems like eye drops which leads to prolonged corneal contact time. (3)
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