FORMULATION AND EVALUATION OF ONCE DAILY SUSTAINED RELEASE MATRIX TABLET OF VERAPAMIL HYDROCHLORIDE

Abstract

Matrix tablets of Verapamil Hydrochloride were formulated as sustained release tablet employing sodium alginate, hydroxyl propyl methyl cellulose polymer, Ethyl cellulose and the sustainedrelease tablets was investigated. Sustained release matrix tablets contain 240 mg Verapamil Hydrochloride were developed using different drug polymer concentration of HPMC, Sodium Alginate and Ethyl Cellulose. Tablets were prepared by wet granulation using HPMCand water solution. Formulation was optimized on the basis of acceptable tablet properties and in-vitro drug release. The resulting formulation produced robust tablets with optimum hardness, thickness consistent weight uniformity and low friability. All tablets but one exhibited gradual and near completion sustained release for Verapamil Hydrochloride, and 99% to 101% released at the end of 24 hrs. The results of dissolution studies indicated that formulation F8, the most successful of the study. An increase in release kinetics of the drug was observed on decreasing polymer concentration. Key words: Verapamil Hydrochloride, Sustained Release, Hydroxyl Propyl Methyl Cellulose, Sodium Alginate, Ethyl Cellulose