Abstract
The microspheres(SBM) was prepared using N, N'-methylene-bis-acrylamide (MBAA) as cross-linker and K2S2O8-Na2SO3 as initiator in water-in-oil emulsion. And then the effects of the O/W ratio (v/v), the amount of cross-linker and the amount of K2S2O8-Na2SO3 on particle size and swelling ratio were investigated. An increase in particle size was observed by increasing the amount of cross-linker and the amount of K2S2O8-Na2SO3, while with decreasing the O/W ratio and the amount of K2S2O8-Na2SO3 particle size was found to decreased, which was just opposite to the trend of swelling ratio. Particle size of the microspheres is 12-65μm. Ascorbic acid was selected as a sample drug, and the function between ascorbic acid and SBM was illustrated by the three-electrode equipment. The absorption mechanism suggested that the absorption of ascorbic acid on SBM is exist and ascribes to hydrogen bond for－OH and－NH2 of SBM and －OH of ascorbic acid.
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