Abstract
A mucoadhesive drug delivery system for systemic delivery of nitrendipine, a calcium channel blocker through buccal route was formulated. Mucoadhesive polymers like hydroxypropylmethylcellulose K-100, hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone K-30 and carbopol-934P were used for film fabrication. The films were evaluated for their weight, thickness, percentage moisture absorbed and lost, surface pH, folding endurance, drug content uniformity, In vitro residence time, In vitro release and ex vivo permeation. Based on the evaluation of these results, it was concluded that buccal films made of hydroxylpropylcellulose and sodium carboxymethylcellulose (5±2% w/v; F-4), which showed moderate drug release (50% w/w at the end of 2 h) and satisfactory film characteristics could be selected as the best among the formulations studied.
Highlights
Mucoadhesive drug delivery systems may be formulated to adhere to the mucosa of eyes, nose, oral, intestine, rectum and vagina[1]
Comfortable compared to the tablets and can circumvent shorter residence time of oral gels[3]
Nitrendipine is a calcium channel blocker used in the treatment of mild to moderate hypertension, chronic stable angina pectoris and Prinz metal’s variant angina[5]
Summary
Mucoadhesive drug delivery systems may be formulated to adhere to the mucosa of eyes, nose, oral (buccal), intestine, rectum and vagina[1]. Comfortable compared to the tablets and can circumvent shorter residence time of oral gels[3]. In vitro drug release was executed by placing one cm diameter film on egg membrane acting as semipermeable membrane.
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