Abstract
The main goal of the current study was to maximize the bioavailability of naringin by prolonging the drug’s release using transdermal patches. Ethyl cellulose (EC) served as the lipophilic component and hydroxy propyl methyl cellulose (HPMC) as the hydrophilic matrix in the preparation of transdermal patches. A 32-complete factorial technique was used to build the optimal design matrix, altering the ratio between the hydrophilic and lipophilic matrices. To create the best optimum formulation, three alternative ratios of EC and HPMC were employed. The patches had pH values ranging from 5.28 ± 0.006 to 5.62 ± 0.015. The transdermal patches had thicknesses ranging from 0.514 ± 0.004 to 0.697 ± 0.004 mm. The average weight of the prepared transdermal patches ranged from 194.67 ± 0.578 to 241.67 ± 1.528 mg. The transdermal patches’ moisture content ranged from 7.23 ± 0.158 to 10.33 ± 0.158%. Tensile strength values of the prepared transdermal patches ranged from 9.59 ± 0.006 to 10.41 ± 0.035 kg/cm2, while the drug content varied from 94.7 ± 0.6 to 97.33 ± 0.208%.
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