Formulation and Evaluation of Nanosponge-based Drug Delivery System of Aceclofenac for Topical application

Abstract

A transdermal drug delivery system using nanosponge and BCS class II drug, Aceclofenac (ACE) was achieved using xerogel as a final dosage form. Blank Beta Cyclodextrin based nanosponge (CDNS) were loaded with aceclofenac to formulate ACE loaded CDNS not only can be effectively treated for osteoarthritis but also successfully evaluated using ex vivo skin permeation studies. Methods used for formulation of ACE loaded CDNS were found out to be effective and accomplished 89.29±2.59% drug entrapment. The optimized formulation had % drug loading of 72.16±3.13%. The zeta potential of the ACE-loaded CDNS was found to be -27.3±1.1mV. A zeta potential value close to ±30mV indicates good physical stability of the micro particles on account of electrostatic repulsion. ACE-loaded CDNS released more than 90% drug in just 150mins (2.5hrs) whereas the marked formulation and ACE drug released more than 90% drug in 240mins (4hrs) and 330mins (5.5hrs) respectively. The conclusion of the current work can be drawn as ACE-loaded CDNS based gel has the potential to improve the transdermal bioavailability of aceclofenac against osteoarthritis with less adverse actions.