FORMULATION AND EVALUATION OF NANOPARTICLES WITH NEURO PROTECTIVE CHEMICALS OF NATURAL AND SYNTHETIC ORIGIN.

Abstract

Most of the active phytoconstituents under development are poorly water soluble or have poor bioavailability . Nanotechnology is an approach to overcome the challenges of conventional drug delivery systems and limitations of phytochemicals. Solid Lipid nanoparticles show interesting features concerning therapeutic purposes. The main advantage is that they are prepared with physiologically well-tolerated lipids.Solid Lipid Nanoparticles (SLNs) as novel lipid based nanocarriers with size range between 10 to 1000nm. SLNs were introduced to overcome problems of polymeric nanoparticles.In present research formulation and evaluation of nanoparticles with ethanolic extract of two plants Celastrus paniculatus and Bacopa monnieri along with Donepezil as a standard drug was undertaken here for the production methods for preparation of SLNs, and pharmaceutical approach of SLNs in drug delivery . The focus of nanoparticle design over the years has evolved toward more complex nanoscopic core–shell architecture using a single delivery system to combine multiple functionalities within nanoparticles which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes, have emerged as a robust and promising delivery platform. Solid liquid nanoparticles having plant extracts were successfully formulated and characterized for their stability.A biodegradable polymeric core is surrounded by a shell composed of layer(s) of phospholipids. This architecture can provide advantages such as controllable particle size, surface functionality, high drug loading, entrapment of multiple therapeutic agents, drug release profile,and good serum stability of phytochemicals