Formulation and Evaluation of Mucoadhesive Tablet of Ondansetron HCl

Abstract

The aim the study was to prepare and evaluate stomach specific mucoadhesive tablet of ondansetron HCl to remain in the stomach for 12hrs. The mucoadhesive tablets were prepared by wet granulation method using HPMC K100M, carbopol 934p, chitosan and xanthan gum as mucoadhesive polymeric material. Characterization of drug, drug andexcipient compatibility among the formulation component were assessed by FTIR and DSC. It was concluded that A6 batch prepared by using HPMC K100M and chitosan showed good release of drug. It passes as per dissolution acceptance criteria for sustained release formulation. It also showed good mucoadhesive strength.