Abstract
Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl methyl cellulose (K4M), hydroxy propyl methyl cellulose (K15M), sodium carboxy methyl cellulose and poly vinyl pyrolidone (K30), plasticizer poly ethylene glycol (400) and a backing membrane of Eudragit (RL100). The films were evaluated in terms of swelling, residence time, mucoadhesion, release, and organoleptic properties. The optimized films showed lower release as compared to controlled drug delivery systems. Hence, an inclusion complex of acyclovir was prepared with hydrophilic polymer hydroxylpropyl beta-cyclodextrin in the molar ratio of 1:1. The inclusion complex was characterized by optical microscopy, FAB mass spectroscopy, and FTIR spectroscopy. Patches formulated with the acyclovir inclusion complex were evaluated along the same lines as those containing acyclovir alone. The in vitro release data revealed a substantial increase from 64.35% to 88.15% in the case of PS I and PS II batches, respectively, confirming the successful use of inclusion complexes for the formulation of buccal patch of acyclovir.
Highlights
Buccal delivery of drugs provides an attractive alternative to the oral route of drug administration, par-A
Many mucoadhesive buccal films have been formulated to release drugs locally in order to treat for fungal infections in the oral cavity, such as oral candidiasis (Donnelly et al, 2007; Khanna et al, 1997; Rapka et al, 2003; Senel et al, 2000)
The present study is aimed at formulating patches to act as transmucosal drug delivery systems containing the drug acyclovir and compare these with patches made with an inclusion complex of acyclovir, in order to improve oral bioavailability
Summary
Buccal delivery of drugs provides an attractive alternative to the oral route of drug administration, par-. Due to the versatility of the manufacturing processes, the release can be oriented either towards the buccal mucosa or towards the oral cavity (Morales, McConville, 2011). These dosage forms are usually prepared by casting a solution of the polymer, drug and any excipients (such as a plasticizer) on to a surface and allowing it to dry. The present study is aimed at formulating patches to act as transmucosal drug delivery systems containing the drug acyclovir and compare these with patches made with an inclusion complex of acyclovir, in order to improve oral bioavailability
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