Abstract
The present project was carried out to formulate and evaluate the mucoadhesive bilayered buccal tablet of Ziprasidone Hcl. Ziprasidone HCl is an antipsychotic agent with half-life of about 2hrs and shows extensive metabolism i.e the drug concentration is < 5% after elimination in the body. The formulations (F1 to F6) were developed which comprises of polymers such as Hydroxypropyl methyl cellulose (HPMC K-15), Polyvinyl pyrollidine (PVP K-30) in various concentrations along with carbopol to achieve the desired characteristics. Mucoadhesive bilayered buccal tablets were fabricated with the aid of direct compression technique and the prepared formulation was evaluated for its physicochemical parameters along with evalauation test. The results from different evaluation test demonstrated that the formulation F1 containing HPMC (25 mg) and CP (10 mg) was selected as optimised formulation and result values of precompression parameters were within the limits and post compression results showed the mucoadhesive strength of F1 formulation was 25.27gm, the drug release at 8th hr was 85.7 % and the formulation was stable throughout the stability studies. Hence mucoadhesive bilayered buccal tablets of Ziprasidone HCl can be prepared. Based on the above results it can be stated that mucoadhesive bilayered buccal tablets can be successfully developed. Formulation described that the nature of tablet depends not only on the se lected polymer excipient but also on the concentration of polymers selected. 
 Keywords: Ziprasidone HCl, Bilayered Buccal Tablet, Mucoadhesion.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.