Abstract
The purpose of this research was to develop mouth dissolve tablets of cinnarizine by effervescent, superdisintegrant addition and sublimation methods. All the three formulations were evaluated for disintegration time, hardness and friability, among these superdisintegrant addition method showed lowest disintegration time; hence it was selected for further studies. Further nine batches (B1-B9) were prepared by using crospovidone, croscarmellose sodium and L-HPC in different concentrations such as 5, 7.5 and 10%. All the formulations were evaluated for weight variation, hardness, friability, drug content, in vitro disintegration time, wetting time, in vitro dissolution. Formulation with 10% L-HPC showed the less disintegration time (25.3 s) and less wetting time (29.1 s). In vitro dissolution studies showed total drug release at the end of 6 min.
Highlights
The purpose of this research was to develop mouth dissolve tablets of cinnarizine by effervescent, superdisintegrant addition and sublimation methods
Technique that are frequently employed in the preparation of mouth dissolving tablets include, freeze drying, sublimation, spray drying, moulding, mass extrusion and direct compression[1]
Mouth dissolving tablets of cinnarizine were prepared by effervescent, superdisintegrant addition and sublimation technique by direct compression method
Summary
The purpose of this research was to develop mouth dissolve tablets of cinnarizine by effervescent, superdisintegrant addition and sublimation methods. All the three formulations were evaluated for disintegration time, hardness and friability, among these superdisintegrant addition method showed lowest disintegration time; it was selected for further studies. It was select as a model drug for the preparation of mouth dissolving tablets. Mouth dissolving tablets of cinnarizine were prepared by effervescent, superdisintegrant addition and sublimation technique by direct compression method. For tablets prepared by effervescent method, specified quantity of cinnarizine, mannitol, Avicel 102, aspartame, talc and magnesium stearate were weighed accurately and passed through 60 # screen.
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