Abstract
Objectives: The objective of the present study was to formulate the metronidazole tablets using natural Aloe vera gum as binding agent.
 Materials and Methods: To determine the binding properties of the extracted A. vera gum were used for the preparation of metronidazole tablets and compared with other binding agents such as acacia and sodium carboxymethyl cellulose (CMC). Physical properties such as hardness, friability, disintegration time, and in vitro dissolution rate are the important parameter which determines for each formulation. Three batches of metronidazole tablets are prepared using acacia (F1), sodium CMC (F2), and A. vera gum (F3) as binding agent.
 Results: The granules were evaluated by determining the angle of repose (26.01 ± 0.110–27.18 ± 0.166°), bulk density, tapped density, Hausner ratio, and Carr’s index. It shows satisfactory results. At time 90 min, the percentage release of drug for F1, F2, and F3 was 44.947%, 31.467%, and 53.424%, respectively. The tablets prepared with A. vera gum showed faster release profile than other binders.
 Conclusion: From the results, it was shown that tablets prepared with A. vera gum have good binding properties and also helped tablets for faster release.
Highlights
Dosage forms usually consist of several materials, in addition to the drug that they convey to the patient
The tablets prepared with A. vera gum showed faster release profile than other binders
From the results, it was shown that tablets prepared with A. vera gum have good binding properties and helped tablets for faster release
Summary
Dosage forms usually consist of several materials, in addition to the drug that they convey to the patient These materials are generally referred to as tablet excipients. Binders are pharmaceutical excipients that are commonly used in tablet formulations to mix the powders properly and form proper granules and generally improve the flow properties of the granules [3, 4]. They modify the binding properties of the granules by promoting the formation of strong cohesive bonds between particles [5]. A number of plant gums/hydrocolloids have been used as binding agents, suspending or emulsifying agents in both solid and liquid dosage forms [8, 9]
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