Abstract

Background and objective: Applying liposomal gels in transdermal drug delivery system has evoked considerable interest because of their good activity for osteoarthritis. The aim of present study was to prepare and characterize liposomes of NSAIDS drug meloxicam, which may deliver these drugs to the target site more efficiently and also overcome the problem related with oral drug delivery of the drug. Methodology: In the present investigation efficiency of liposomes as a novel lipid for topical delivery of meloxicam has been evaluated. Liposomes were optimize by varying concentration of phospholipids cholesterol and ethanol. Liposomes formulation with soya lecithin, cholesterol and ethanol was optimized. Result: On characterization spherical, unilamellar vesicle with smooth surface were observed under Scanning electron microscopy and F4 formulation shows the best result. Conclusion: Suggested as liposomes as an efficient carriers for meloxicam topical drug delivery.

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