Abstract
Mefenamic acid ( MA) s olid Dispersions were prepared employing methanol as a common solvent using PEG - 4000 as a drug carrier with two different techniques namely, melting method and solvent evaporation in varied ratios. The prepared solid d ispersions were evaluated and com pared with that of pure drug (mefenamic acid) in respect to the dissolution rate and dissolution efficiency . It is noted that s olid dispersions of mefenamic acid showed a remarkable increase in dissolution r ate and dissolution efficiency. An increase in th e dissolution rate was observed with an increase in PEG - 4000 concentration with regarding to solvent evaporation method.Dissolution rate of mefenamic acid was found to beincreased 8.14 folds with mefenamic acid - PEG - 4000 solid dispersion (1:2) ratio, in ca se of solvent evaporation method, and 6.51 folds with mefenamic acid - PEG - 4000 solid dispersion (1:1 ) ratio. PEG - 4000 can be used in order to raise the dissolution rates of poorly soluble drugs such as mefenamic acid.
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