Abstract
Nanotechnology mediated drug delivery has been reported to enhance the drug efficacy, bioavailability, reduced toxicity and improve patient compliance by targeting the cells and tissues to elicit the desired pharmacological action. The main aim of the study was to formulate lovastatin loaded nanosponges and to evaluate them. Lovastatin loaded nanosponges were prepared by Emulsion solvent diffusion method using different polymers (Ethyl cellulose, Polyvinyl alcohol, β-cyclodextrin, Pluronic F68, Hydroxy Propyl β- cyclodextrin). The FTIR test is conducted as the preliminary test, by this test there was no interaction between the drug and polymers. Then nanosponges were evaluated for particle size, PDI, zeta potential, SEM, entrapment efficiency and invitro drug release. The particle size ranged from 295.5 to 578.8 nm, PDI ranged from 0.189 to 0.465, zeta potential from -17.3 to -35.96 mV and entrapment efficiency was ranged from 78.38 to 95.77 %. The cumulative percentage release from all nanosponges varied from 66.86 to 96.60% after 12 hours depending upon the drug and polymers ratio andF6 formulation showed highest drug release i.e., 96.60%. The release kinetic studies showed that the release first order diffusion controlled and the n value (0.6017) from the Korsmeyer-Peppa’s model indicated the release mechanism was non-fickian type.
Highlights
Nanosponges are made of microscopic particles with few nanometers’ wide cavities, in which a large variety of substances can be encapsulated
An FT-IR spectroscopy study has been carried out separately to check the compatibility between the drug (Lovastatin) and the polymers (EC, PVA, β – CD, PL- F68 and HP-β -CD) used for the preparation of Nano sponges
Characterization of Nanosponges Lovastatin loaded nanosponges were prepared by Emulsion solvent diffusion method
Summary
Nanosponges are made of microscopic particles with few nanometers’ wide cavities, in which a large variety of substances can be encapsulated. These particles possess the ability to carry both lipophilic and hydrophilic substances and thereby improving the solubility of poorly water-soluble molecules. The nanosponge is about the size of a virus with a ‘backbone’ (a scaffold structure) of naturally degradable polyester. They ‘cross link’ segments of the polyester to form a spherical shape that has many pockets (or cavities) where drugs can be encapsulated. The polyester is biodegradable, which means that when it breaks down in the body, the drug can be released on a known schedule [2]
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