Abstract
Objective: Objective of the present investigation was to enhance the solubility and dissolution rate of poorly water-soluble drug lornoxicam using liquisolid technique with comparative determination of in vitro release profile of liquisolid compacts and conventional formulation of lornoxicam.
 Methods: Formulation was prepared by a liquisolid technique using different drug concentration in a liquid vehicle and different carrier/coating ratio. Prepared liquisolid compact was evaluated for Fourier transform infrared (FTIR) spectra analysis, differential scanning calorimetry (DSC), X-ray diffraction (P-XRD), scanning electron microscopy (SEM) and in vitro dissolution study.
 Results: The result showed that liquisolid compacts of lornoxicam displayed significantly higher drug release rate as compared to pure drug and conventional tablet prepared. The results of both DSC and X-ray crystallography indicated loss of crystallinity of the drug upon formulated into the liquisolid compact.
 Conclusion: Dissolution rate of the drug from liquisolid compacts was affected by changing the drug concentration and excipient ratio. The liquisolid technique appeared to be a promising approach for improving the dissolution of poorly soluble drug lornoxicam.
Highlights
The increased emergence of poorly water-soluble active compounds presents specific obstacles for the development of both immediate release and modified release dosage forms
The present research involves enhancement of the solubility and dissolution rate of poorly water-soluble drug lornoxicam using the liquisolid technique with comparative determination of in vitro release profile of liquisolid compacts and conventional formulation of lornoxicam
Result is shown in fig. 7, with a calculated similarity factor (f2 value) of 67.18 and dissimilarity factor (f1 value) of 5.7. It can be concluded from the observations that formulation LS–4 optimally achieved the objectives of preparation of liquisolid compact of lornoxicam i.e. enhanced drug dissolution and solubility
Summary
Formulation was prepared by a liquisolid technique using different drug concentration in a liquid vehicle and different carrier/coating ratio. Prepared liquisolid compact was evaluated for Fourier transform infrared (FTIR) spectra analysis, differential scanning calorimetry (DSC), Xray diffraction (P-XRD), scanning electron microscopy (SEM) and in vitro dissolution study
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