Formulation and Evaluation of Intrapacket Dental Film of Antibacterial agent for Periodontitis

Abstract

Periodontal disease causes destruction of adjuvant structures of the teeth predominate in all groups, ethnicities, races and both genders. Systemic antibiotic therapy is employed in treating this diseased condition, but it has limited due to the lack of accessibility to periodontopathic organisms in the periodontal pocket. These controlled intra-pocket devices also help in the maintenance of therapeutic drug concentration for the desired period of time. The goal of this research was to fabricate controlled release dental films, loaded with Tinidazole as an antimicrobial agent which consists of a common nonbiodegradable polymer and a co-polymer in different proportions for targeted delivery of drug. Nine formulations of Tinidazole dental films were prepared with ethyl cellulose as the main common non- biodegradable polymer and different co-polymers like PVPK30, HPMC K4M, Eudragit RL 100 in three ratios using solvent casting method. These films were evaluated for various parameters like thickness uniformity, content uniformity, swelling index, percentage moisture loss, in vitro drug release studies etc. Based on these parameters best film was selected as the one which is prepared with ethyl cellulose and eudragit RL100 (20%w/w of ethyl cellulose) i.e F5, since it can release the drug above MIC in each day of treatment and it is having sufficient drug content and other required film characteristics. The kinetic models of the formulation F5 was then found and it indicated that the formulation undergoes zero order release kinetics and model fits to Higuchi which is indicative of the diffusion mechanism of drug release. The mechanism of drug release was found to be Non-Fickian. From all of these studies it was concluded that Ethyl cellulose - Eudragit RL100 (20%w/w of EC) combination is the best carrier among the other polymers for the Tinidazole film for the treatment of periodontitis.