Abstract
The purpose of this research is to prepare metformin hydrochloride immediate release tablets by wet granulation technique. In order to obtain the best, optimized product ten different formulations were developed. Different binder, disintegrants and lubricants taken as variables. Weight variation, thickness, hardness, friability, disintegration time, in-vitro release and pharmaceutical assay were studied as response variables. Capping was observed in formulation containing PVP K-30. However, in the remaining formulation containing PVP K-90, no capping was observed. The formulation A7 was selected as optimized formulation. The different physical properties and in-vitro release profile showed best comparable with the reference product. Optimization has proven an effective tool in product development.
Highlights
Oral route of drug administration is perhaps the most appealing route for the delivery of drugs
The main use for metformin is in the treatment of diabetes mellitus Type-II, especially when this accompanies obesity and insulin resistance. metformin is the only anti-diabetic drug that has been proven to protect against the cardiovascular complications of diabetes
This was first shown in the United Kingdom Prospective Diabetes Study, a large study of overweight patients with diabetes
Summary
Oral route of drug administration is perhaps the most appealing route for the delivery of drugs. Metformin is an oral anti-diabetic drug from the biguanide class. It is the first-line drug for the treatment of type-II diabetes, in overweight and obese people and those with normal kidney function, and evidence suggests it may be the best choice for people with heart failure[3,4]. Metformin is the only anti-diabetic drug that has been proven to protect against the cardiovascular complications of diabetes. This was first shown in the United Kingdom Prospective Diabetes Study, a large study of overweight patients with diabetes. Unlike the other most-commonly prescribed class of oral diabetes drugs, the sulfonylurea, metformin (taken alone) does not induce hypoglycemia. The objective of the present study was to develop Telmisartan (IR) immediate release tablets using super disintegrants like
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