Abstract
The objective of the present study was to formulate the gastro-retentive floating tablets containing Ibuprofen, which would remain in stomach and/or upper part of GIT for prolonged period of time. Floating systems have low bulk density so that they can float on the gastric juice in the stomach. Ibuprofen is an anti inflammatory drug. On trial and error basis formulation design was done. Four different batches of floating tablets of Ibuprofen were prepared using HPMC, Xanthan gum, and gas generating agent sodium bicarbonate and citric acid. The tablets were characterized for the pre and post compression parameters such as friability, hardness, thickness, drug content, weight variation, in-vitro buoyancy studies and 13 hrs in-vitro drug release studies and the results were within the limits. From the results obtained, it was concluded that the optimized formulation F4 desired drug release properties and floating behavior.
Highlights
Formulation and evaluation of Ibuprofen gastro-retentive floating tablets
HPMC K4M, Xanthan gum, Citric acid, lactose and Sodium bicarbonate, Talc and MCC were obtained from Research Lab, Akola, Maharashtra, India
In vitro release studies In vitro drug release study for the prepared Ibuprofen floating tablets were conducted for period of 13 hours using a six station USP XXVI type II apparatus at 37±0.50C and 50 rpm speed
Summary
Formulation and evaluation of Ibuprofen gastro-retentive floating tablets. This results in an increased Gastric retention time and a better control of the fluctuations in plasma drug concentration[4]. The main intention of this work was to formulate a single unit floating tablets of ibuprofen with use of HPMC for the release of the drug after a definite lag time and provides required concentration of drug at regular intervals of time which results reduction in frequency of dose of administration and will improve patient compliance[12].
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