Abstract
Objective: To formulate arthritic pain relieving tablets and evaluation of tablets.
 Methods: The preparation of dry powder of Nyctanthes arbor-tristis leaves, 1% Acacia solution, 1%HPMC-10 solution, 1% Sodium alginate solution. The wet granulation method was used for the formulation of herbal tablets.
 Results: Based on the pre-formulation study, the flow property of granules was good. The physical parameters of compressed tablets color were Greenish white for F1 and F3 batch, Dark greenish-white color for F2batch. The weight variation test, hardness, thickness, friability and disintegration time for F1 batch was found to be [497±5%, 3.3±0.17, 4.00±0.005, 0.81%, 28] respectively, For F2 batch [506±5%, 3.13±0.01, 3.66±0.023, 1.43%, 25] respectively, For F3 batch [502.5±5%, 3.13±0.01, 3.96±0.001, 1.8%, 32] respectively.
 Conclusion: The formulated herbal tablets were used to manage arthritic pain. Based on the results, it is concluded that the formulation and evaluation of herbal tablets were good.
Highlights
Nyctanthes arbor-tristis is a traditional medicinal plant, which belongs to family Oleaceae
Nyctanthes arbor-tristis leaves were collected from the local area dried, powdered and used as an antipyretic, analgesic, anti-inflammatory to cure arthritis, joint pains etc
The excipients used in the formulation are Methylcellulose is used as disintegrate, Magnesium stearate is used as a lubricant, Lactose is used as the diluent, Talc is used as a lubricant and gives the pleasant appearance to the tablet, and Acacia, HPMC-10, Sodium alginate these three excipients are used as the binder for the preparation of wet granulation
Summary
Nyctanthes arbor-tristis is a traditional medicinal plant, which belongs to family Oleaceae. The Nyctanthes arbor-tristis is a shrub or tree having fragrant flowers. The plant generally grows in the tropical and subtropical regions [1,2,3]. The Nyctanthes arbor-tristis having various names like Parijat, Night Jasmin, Coral Jasmin, Harsinghar, etc. There are several Hindu religious stories related to the Nyctanthes arbor-tristis (Parijat). The holistic connection of the Parijat plant with Bhagwat Purana, The Mahabharata and Vishnu Purana. The Nyctanthes arbor-tristis is called as “Tree of Sorrow” because of the loss of the flowers their brightness during day time. The plant name arbor-tristis means the sad tree [4, 5]
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