Abstract
Abstract: The present study outlines a systematic approach for designing and development of Glipizide floating tablets to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of Glipizide have shown controlled release thereby proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration. Different formulations were formulated by wet granulation technique using HPMC K100M (floating agent) and Xanthan gum as polymers along with sodium bicarbonate as gas generating agent. The formulations were evaluated for their physicochemical properties, buoyancy lag time, total floating time, swelling index and invitro drug release. It was found that the hardness of the tablets affects the Buoyancy characteristic of the dosage form. All nine formulations possessed good floating properties with total floating time between 8 – 12 hrs.
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