Abstract
Many approaches have been immerged to prolong the residence time of the dosage forms at the absorption site .One among them is the development of oral controlled release mucoadhesive system. The present study aims to formulate and evaluate the effectiveness of FSM-Alginate beads of Vildagliptin in streptozotocin induced diabetic rats. In the present work, 6 formulations of Vildagliptin mucoadhesive beads (F1 to F6) were prepared by ionotropic gelation method. Fenugreek seed mucilage and sodium alginate was used as polymers and calcium chloride as cross linking agent. The beads containing drugs and excipients were subjected to various evaluation test such as Particle size distribution, Swelling index, Mucoadhesivity and Dissolution studies. Among all the formulations, F3 containing FSM and sodium alginate in the concentration of 0.6g and % DEE of 97.89 resulting in the highest drug release rate of 97.86% at the end of 10 h. Hence, it was considered as the optimized formulation. Keywords: Mucoadhesion, Fenugreek Seed Mucilage, Sodium Alginate, Diabetes. Ionotropic Gelation.
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