Formulation and Evaluation of Fluconazole Lotion

Abstract

In the present work, Fluconazole -SLNs were successfully prepared by high shear homogenization and ultrasonication technique. The results showed that the entrapment efficiency %, zeta potential, zeta size, morphology, thermal character and the in-vitro drug release from Fluconazole -SLNs dispersion and from Fluconazole -SLNs lotion were greatly affected by the type and concentration of surfactant and concentration of the used lipid which affect the in-vitro antifungal character of the prepared Fluconazole -SLNs lotion. The sustained release behavior of Fluconazole -SLNs gel with favorable physicochemical Properties can form a foundation for further clinical studies using these prepared lotions for topical delivery of Fluconazole. Topical treatment of the skin infection has been mainly used due to its eminence over oral treatment to avoid systemic adverse effects, target the site of infection for application of drug formulation and to increase the patient compliance. The vesicular, colloidal and nanoparticulate carriers systems are used for the topical antifungal treatment. A vesicular carrier such as transferosomes and ethosomes has demonstrated as they increased drug transdermal penetration. Formulation of topical product plays a main role for penetration of the drug through skin. Lipophilicity of drug molecules is also effective parameter in physiochemical property. Some antifungal drugs are more lipophilic compounds which affect the penetration of drugs through stratum corneum. Various formulations have emerged, to optimize new drug delivery carriers for antifungal treatment.