Formulation and evaluation of floating tablet of levofloxacin

Abstract

Floating drug delivery system is a system to retained the drug in the stomach which is applicable only for poorly soluble and less stable in intestinal fluids. It is basis on the dense on gastric fluids which is float on gastric fluids. Floating tablet Formulations of levofloxacin were prepared by simple blending and punching with carbopol, HPMC K4M, sodium bicarbonate, citric acid and talk for oral application. Levofloxacin is an antibiotic drug having higher protein binding, hepatic metabolism low oral bioavailability and lower half life. The drug requires a drug delivery system that provides a solution of these problems and improves bioavailability. Prepared floating batches were characterized for compatibility study, pre compression and post compression evaluation, % drug content, in-vitro drug release. Major advantages of the system include ease of preparation, high % drug release and long duration over 12 hours. From this study, it was concluded that floating tablet batch F3 offers better sustained release in continuous manner that helpful to maintain bioavailability for long duration and reduces frequency of dose, also reduces dose.