Abstract
The present study was aimed to formulate and evaluate floating tablets of indomethacin by wet granulation method. Indomethacin is used as a potent anti-inflammatory drug with prompt anti pyretic action, mainly used for the treatment of osteoarthritis with half-life of 4.5 hrs. Indomethacin is stable in neutral or slightly acidic media. In this study, excipients like HPMC 5cps, sodium bi carbonate were incorporated in a nine different concentrations (F1-F9) along with other excipients (PVP K30, lactose, talc, and magnesium stearate) to formulate floating tablets by wet granulation method. Then all the nine formulations were evaluated for uniformity of weight, hardness, thickness, friability test, floating lag time, drug content, dissolution studies and stability studies. The dissolution profile of trial-6 (formulation 6) was observed to be better than other formulations. In trial-6 indomethacin was formulated as a floating tablet by using HPMC 5cps (120 mg) as a matrix forming polymer and sodium bi carbonate (40 mg) as a gas generating agent. Trial-6 formulation showed a good dissolution profile for a controlled period of time which was noticed to be as 97.78 % at the end of 12th hour. Thus, it can be concluded that the floating drug delivery system of indomethacin using the appropriate polymers in right amount may enhance the activity of the drug by prolonging the gastric residence time or reducing the floating lag time. Keywords: Indomethacin, HPMC 5cps, Sodium bi carbonate.
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