Abstract
Ranolazine is indicated for the treatment of chronic angina alone or in combination with other cardiovascular agents. The objective of present investigation was to formulate floating microspheres of ranolazine to increase gastric residence time, increased bioavailability and reduce dose frequency of drug therapy. Novel o/w emulsion solvent diffusion technique was used for preparation of microspheres of ranolazine by using various polymers such as HPMC (hydroxyl propyl methyl cellulose), ethyl cellulose and Eudragit L 100. Entrapment efficiency of drug was up to 80.16%. Eudragit L100 based microspheres were found to be hollow cavity, spherical and porous nature from the results of scanning electron microscopy. Micromeritic profile of these microspheres was found satisfactory. From the results of FTIR spectroscopy it was revealed that there was no drug--polymer interaction. Eudragit L100 based microspheres shows good in vitro buoyancy and sustained release profile for longer period of time (> 14 hours), suggesting the viability of floating microspheres of ranolazine for improved pharmacokinetics for treatment of chronic angina.
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