Abstract
Lansoprazole has a short half-life and it gets absorbed only in the proximal part of the small intestine. Floating microspheres of such a drug floats on the stomach contents and releases the drug slowly for longer periods of time. Thus, to overcome the problem like short half-life and to enhance the absorption and bioavailability, floating microspheres of lansoprazole were formulated by spray drying method using ethyl cellulose and HPMC E15 as polymers and dichloromethane and ethanol as solvents. Prepared microspheres were evaluated for micrometric properties, percentage yield, drug content, buoyancy percentage, differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). All designed formulations showed in vitro buoyancy between 72 to 92 %. In vitro dissolution study showed cumulative drug release between 84 to 97 % within 8 h. SEM study showed that formulated microspheres were porous and spherical with rough surface.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
