FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY OF CEFOTAXIME USING RAFT FORMING APPROACH

Abstract

The cefotaxime is a broad-spectrum cephalosporin antibiotic. It is mainly used in the treatment of bacterial infections. Cefotaxime is a suitable candidate for controlled release administration due to its short elimination time 1 hour. The main aim of the present investigation is to increase the gastric residence time by preparing floating drug delivery by using raft forming approach thereby improving bioavailability. The prepared Cefotaxime floating drug delivery by using raft forming approach were evaluated for hardness, weight variation, thickness, friability, drug content uniformity, total floating time, In-vitro dissolution studies and buoyancy lag time. Floating tablets were formulated using direct compression technique. Various polymers are used in the formulation they Microcrystalline cellulose used as binder, HPMC K15M, Guargum used as hydrophilic polymers, Chitosan, Sodium bicarbonate was incorporated as an effervescent substance, Sodium alginate used as viscous gel forming agent, Magnesium streate used as lubrication, talc was used as diluent. The formulated Cefotaxime tablet to be evaluated the following parameters as follow Weight variation (mg), Hardness, Thickness, Friability, Drug content uniformity, Floating lag time, the in vitro cumulative amount of drug released was shown the F7 is 99.28% within 45 minutes the comparative studies with marketed formulations F7 show the better results. Keywords: Cefotaxime, Direct compression, Raft forming, floating drug delivery system.