Abstract
Gastro retentive drug delivery systems have been widely used to prolong retention of dosage forms in stomach. Among the various approaches, the floating bilayer tablets formulation offers sustained drug release as well as prolonged gastric retention, along with the added advantage of liquid oral dosage form. The present study was an attempt to formulate and evaluate floating bilayer tablets of Epleronone by using various polymers like guar gum, ethyl cellulose, SSG, CCS. The prepared floating Bilayered tablets were evaluated for hardness, Weight variation, thickness, friability, drug content uniformity, and in-vitro dissolution studies. Based on various evaluation parameters formulation F3 (IR) & F12 (SR) was selected as optimized formulation. From the above floating buoyancy studies shows that F12 shows higher Total floating time than other formulations. It was observed that Formulations F3 (IR) & F12 (SR) gave maximum drug release within time. All formulations were subjected for drug release kinetics studies viz. Zero order, first order, Higuchi matrix, Peppas model equations and the formulations of sustained release (SR) formulations followed zero order release with non-fickian diffusion mechanism.
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