Abstract
Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance. The development of enhanced oral protein delivery technology by mouth dissolving Tablets which may release these drugs in the mouth are very promising for the delivery of high molecular weight protein and peptide. Good mouth feel property of MDDS helps to change the basic view of medication as “bitter pill”, particularly for pediatric patients. To prepare mouth dissolving tablet using SSG & CCM by using Antihypertensive as model drug. Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme and it is a key component of the renin-angiotensin-aldosterone system. The ƛmax of Captopril was determined by scanning the 10µg / ml solution of drug using UV-Spectrophotometer and was found to be 271nm. The linear correlation was found to be 0.9995.The Fast dissolving tablets of captopril were prepared by direct compression method. Captopril can be successfully formulated as mouth dissolving tablets using various super disintegrate in different concentrations by direct compression method. The formulation containing 10% of crospovidone as super disintegrated was found to be outstanding than other formulations in terms of disintegration time and rate of dissolution.
Highlights
Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance [1,2,3]
The oral route remains the perfect route for the administration of therapeutic agents because the low cost of therapy, manufacturing and ease of administration lead to high levels of patient compliance [7,8,9,10]
Calibration of Captopril The ƛmax of Captopril was determined by scanning the 10μg / ml solution of drug using UV-Spectrophotometer and was found to be 271nm.The absorbance of the solution 5 to 25 μg/ml was measured in UV-Spectrophotometer at 271nm.(Table-1)
Summary
Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance [1,2,3]. The primary methods of taste-masking include adsorption onto or complexation with carriers and spray coating of solid dosage forms, which increase consumer choice, for the reason of rapid disintegrate/dissolve in oral cavity within seconds and swallowed without the need of water or chewing [13,14,15]. Fast dissolving drug delivery can be achieved various techniques like direct compression, wet granulation, compression moldings, volatization and freeze – drying. They involve different mechanisms like use of high amounts of hydrophilic disintegrating agents which allow the dosage forms to disintegrate quickly in the patient’s mouth on contact with saliva [16,17]. Corresponding author: Akash S.Ahire KYDSCT COP,sakegaon , Bhusawal, Dist-Jalgaon (MH) INDIA
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