FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ACECLOFENAC USING NATURAL SUPERDISINTEGRANT

Abstract

On contact with saliva, FDTs (Fast dissolving tablets) which are designed to disintegrate rapidly, enables tremendous oral administration without contact with water. Also chewing these formulations produces an increased convenience and ease of administration with a significant potential efficacy to improve the patient compliance, predominantly in certain populations who were facing difficulties for swallowing the conventional solid oral dosage forms. In our present study, the effect of a natural superdisintegrant namely, Fenugreek and some synthetic superdisintegrants such as SSG (Sodium Starch Glycolate), MCC (Micro Crystalline Cellulose), CP (Cross Povidone) and CCS (Cross Carmaellose sodium) were employed for this study to produce the formulations of FDTs. By direct compression method, FDTs of Aceclofenac were prepared and evaluated as per IP standards. From our study it was confirmed that Fenugreek showed excellent swelling index than the synthetic superdisintegrants. Hence the present study reveals that this natural superdisintegrants showed significant disintegration.