Abstract
Difficulties of swallowing and first-pass metabolism are of the major limitations of oral medicaments resulting in patient non-compliance and poor oral bioavailability. These drawbacks can be avoided by the administration of alternative dosage forms e.g. mouth dissolving tablets (MDTs) that dissolve upon contact with saliva and consequently allowing systemic drug absorption via buccal mucosa. This study aimed to prepare MDTs Ofloxacin containing superdisintegrants and effervescent agents. MDTs were prepared using different excipients where powdered blends were evaluated to investigate their flow properties followed by physical characterization of the directly compressed tablets. Formula (F6) containing 20mg crospovidone and effervescent base as a disintegration-aiding agent achieved the best results according to the standard specifications.
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