Abstract
Orally disintegrating tablets : formulation, preparation techniques and evaluationPriyanka Nagar, Kusum Singh, Iti Chauhan, Madhu Verma, Mohd Yasir,Azad Khan, Rajat Sharma, Nandini Gupta
Highlights
Therapeutic efficacy depends upon bioavailability, solubility, and release of drug molecules from the formulation
The nanoparticles showed a remarkable increase in the aqueous saturation solubility i.e., NP1, NP2, NP3 and NP4 shows 4.4, 4.6, 7.7 and 7.8 folds respectively increase in aqueous solubility as compared to VLZ
It seems that VLZ and Vilazodone nanoparticles (VLZNP) elicited significant antidepressant-like activity
Summary
Therapeutic efficacy depends upon bioavailability, solubility, and release of drug molecules from the formulation. The aqueous solubility of therapeutically active substance governs dissolution, absorption and has an essential role in bioavailability of oral drug formulations (Patel et al, 2011). About more than 40% of drug molecules recognized during combinatorial selection programs are poorly water soluble. Low aqueous solubility is main trouble in formulation development, clinical testing and during screening new compounds for therapeutic activity (Lipinski, 2002). The low water solubility of many active pharmaceutical ingredients (APIs) excludes their use in certain clinical applications in spite of their efficacy. Small particle formation technologies for these APIs may increase
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