Abstract
Introduction: Fast-dissolving oral delivery system is a solid dosage form, which is used as a novel approach, as it dissolves rapidly in the mouth and directly reaches the systemic circulation. This facilitates rapid absorption and reduces first-pass effects. These films provide better utilization without the need to chew and do not require the need of water for administration. Fast-dissolving oral films might be useful in special patients like those with swallowing difficulties and in that in chemotherapy. This study was aimed to formulate and evaluate the fast dissolving oral films of Cetirizine Hydrochloride.
 Methods: Oral films of Cetirizine Hydrochloride were prepared using Hydroxy Propyl Methyl Cellulose (HPMC), Polyvinyl alcohol, glycerol, aspartame in different concentrations by the solvent casting method. Films were evaluated for different physical Films were subjected to USP dissolution studies.
 Results: The drug content of the nine formulations was found to be in the range as per Indian Pharmacopeia. In vitro release studies indicated 60-91% release within 30 min in the formulated oral films. The best release was found to be 91.58% of formulation F7, having a minimum concentration of HPMC alone as a polymer along with other common ingredients and minimum release was found to be 60.01% of formulation F1. Surface pH was found to be near to neutral (pH 7) which was good for buccal mucosa.
 Conclusion: Increasing the concentration of polymer (PVA and HPMC) while keeping the plasticizer ratio constant showed enhanced folding endurance. The dissolution rates were also increased with the increase in the concentration of the polymers. The high concentration of polymers decreased the release rate of cetirizine while a low concentration of polymers causes an increment in the release rate of cetirizine.
Highlights
Oral route is the most preferred route for the drug delivery system
The novel approach of fast dissolving oral films can be advantageous to patients with swallowing difficulties or cancer patients to bypass the emetic side effects of chemotherapeutic agents
Calibration curve: Standard solution of different concentrations of Cetirizine hydrochloride was prepared and their absorbance was measured in UV spectrophotometer at 231 nm in distilled water
Summary
Oral route is the most preferred route for the drug delivery system. About 60% of all dosage forms available are oral solid dosage form. It does not cause drowsiness or anticholinergic side effects. many cetirizine tablets are potent and useful but due to their bitter and elegant taste and smell, and difficulty in swallowing, a patient feels uncomfortable to take them.. It does not cause drowsiness or anticholinergic side effects. many cetirizine tablets are potent and useful but due to their bitter and elegant taste and smell, and difficulty in swallowing, a patient feels uncomfortable to take them.5 To overcome such problems the present study is carried out to formulate fast dissolving films of cetirizine hydrochloride. Fast-dissolving oral delivery system is a solid dosage form, which is used as a novel approach, as it dissolves rapidly in the mouth and directly reaches the systemic circulation This facilitates rapid absorption and reduces first-pass effects. This study was aimed to formulate and evaluate the fast dissolving oral films of cetirizine hydrochloride
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