Formulation and evaluation of fast disintegrating tablet of glimepiride

Abstract

Glimepiride is the third generation sulphonylurea agent, used for the treatment of type II diabetes mellitus. Glimepiride is given once daily in doses from 1-4 mg. The objective of the present study was to formulate and evaluate the fast disintegrating tablets of Glimepiride. Method: The fast dissolving tablets of glimepiride were prepared by direct compression method by using different disintegrating agents. The drug and the excipients were evaluated for angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio for the determination of flow property of the powder. The formulated tablets were evaluated for thickness, hardness, friability, wetting time, water absorption ratio, and dissolution and disintegration time. Result: Fast disintegrating tablets were successfully prepared by direct compression method. The disintegration time was less than 1 minute which is acceptable. The obtained results clearly indicated that the prepared tablets of glimepiride were fast disintegrating. Conclusion: The fast disintegrating tablets of glimepiride are prepared with disintegrating time less than 1 minute, this will help in future for further improvement of dosage and formulation and will help to control immediately the rise glucose level of chronic diabetic patients.