Abstract
Pluronic® F-127 gel was evaluated as a potential topical vehicle for epidermal growth factor delivery. The chemical stability of the polypeptide within the gel matrix was investigated using HPLC. Thermal stability studies were performed on the base gel formulation. Modifications to the formulation were made to improve physical characteristics and chemical stability. Humectants and antioxidants were investigated as potential formulation additives and the microbial status of the product was also evaluated. A formulation containing 10% propylene glycol as humectant showed both physical and chemical stability for 3 months when stored in a refrigerator. Kinetic studies were performed on thermal stability data obtained and apparent degradation rate constants were calculated. The degradation of the epidermal growth factor within the formulation appears to follow Arrhenius kinetic, with an apparent energy of activation of 93 kJ. per mole.
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