FORMULATION AND EVALUATION OF DICLOFENAC TOPICAL GEL WITH ANALGESIC ACTIVITY

Abstract

The present investigation is concerned with formulation and Evaluation of Diclofenac topical gel an anti-inflammatory, analgesic drug to circumvent the first pass effect and to improve its bioavailability with reduction in dosing frequency and dose related side effects. The diclofenac gel were prepared by using different concentration of different polymers. Six formulations were developed with varying concentrations of polymers like Carbopol, HPMC. The gels were tested for clarity, homogeneity, washability, spreadabiliy, PH, percentage drug content, skin irritation, permeability studies. From the study it was concluded that HPMC gel containing diclofenac sodium showed good consistency, homogeneity, spreadability, washability and permeability and has wider prospect for topical preparations as compared to Carbopol gel containing diclofenac sodium.