Abstract
Carvedilol Phosphate Osmotic Tablets were prepared using a Direct Compression approach. A mixture of osmogens i.e. NaCl and Mannitol was used to achieve a desired osmotic pressure in the tablets which were then coated with Cellulose Acetate polymer with PEG as a plasticizer and Povidone K30 as a pore former. Early screening batches showed drastic effect of osmogens and pore former, as well as % weight gain on drug release of the tablets. The prepared tablets were evaluated for Weight variation, Thickness, Hardness, Dissolution, and the final optimized formulation was exposed to Accelerated Stability Study. A full factorial statistical optimization was carried out on the best optimized formulation to establish the design space for selected factors i.e., NaCl and Povidone K30 against Response Dissolution. A significant effect of both factors was found on Dissolution rate, which justifies the use and rationale of the excipients
 Key Words: Carvedilol Phosphate, Osmotic Tablets, Direct Compression, NaCl, Mannitol, Cellulose Acetate.
Highlights
IntroductionIntroduction of Drug Delivery System1.1.1 Osmotic Drug Delivery Systems: - [1, 2]Customary medication conveyance frameworks have little authority over their medication discharge and no influence over the fruitful fixation at the objective site
Introduction of Drug Delivery System1.1.1 Osmotic Drug Delivery Systems: - [1, 2]Customary medication conveyance frameworks have little authority over their medication discharge and no influence over the fruitful fixation at the objective site
The drug and drug-polymer mixture (1:1) were mixed with dried potassium bromide and compressed under 10-ton pressure for 5 min in a hydraulic press to form a transparent pellet. These pellets were scanned in the region of 4000 to 400 cm-1using a Shimadzu FTIR 1700 Spectrophotometer. 5.2 Dose Calculation 5.2.1 Dose Calculation for Carvedilol Phosphate for Controlled release Dosage form:For controlled release dosage form, Dose calculation for 24 hrs is calculated by below equation; DT = DL (1+0.693 x t/t1/2) Where, DT = Total Dose, DL = Loading Dose – 12.5 mg of Carvedilol Phosphate t = Time require for drug release – 24 hrs, t1/2 = half life of drug: 7 hrs DT = 12.5 (1+0.693 x 24/7) = 42.2 mg of Carvedilol Phosphate
Summary
Introduction of Drug Delivery System1.1.1 Osmotic Drug Delivery Systems: - [1, 2]Customary medication conveyance frameworks have little authority over their medication discharge and no influence over the fruitful fixation at the objective site. 1.1.1 Osmotic Drug Delivery Systems: - [1, 2]. Customary medication conveyance frameworks have little authority over their medication discharge and no influence over the fruitful fixation at the objective site. This sort of dosing example may result in ceaselessly changing, irregular plasma fixations. Medications can be conveyed in a controlled model over an extensive stretch of time by the controlled or adjusted discharge tranquilizes conveyance frameworks. They contain dose shapes for oral and transdermal association and infuse capable and implantable frameworks. Distinct kind of atoms may have low oral bioavailability due to dissolvability or penetrability confinements
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