Formulation and Evaluation of Colon Specific Pulsatile Drug Delivery System of Zidovudine

Abstract

Traditional dosage forms are vastly outclassed by PDDS (pulsatile drug delivery systems). It is more effective than regular doses since it is delivered at the proper time, location, and dose. After a lag period, the medication is delivered as a whole pulse. The release profile of these products is sigmoid. Chronopharmacological drugs and pharmaceuticals with a first-pass effect benefit from these systems. The early research of zidovudine as an anticancer therapy had mediocre results, thus it is presently utilised to treat HIV-infected individuals as a thymidine analogue. For the medicine Zidovudine, a colon-specific pulsatile drug delivery system was developed and assessed across a range of parameters. Proved Zidovudine's colon-specific administration, the pill demonstrates a five-hour lag time with 5 per cent drug release and 99 per cent in 24 h.