FORMULATION AND EVALUATION OF CHLORPHENOXAMINE HYDROCHLORIDE RAPIDLY DISINTEGRATING TABLETS

Abstract

Th e aim of the present study was to develop rapid disintegrating tablets of C hlorophenoxamine hydrochloride which acts as antihistaminic , anticholinergic , antipruritic and antiparkinsonian agent . Chlorphenoxamine Hydrochloride is present in the market as conventional tablets with very low bioavailability due to first pass effect . To increase its bioavailability; rapidly disintegrating tablets of chlorophenoxamine hydrochloride to be dissolved and disintegrate quickly in the mouth cavity and reach to the systemic circulation more quickly than conventional tablets. Rapid disintegrating tablets o f Chlorophenoxamine h ydrochloride were prepared by using different superdisintegrants such as Aci - Di - Sol, crosspovidone and sodium starch glycolate with two different concentrations 2.5 mg and 5 mg . The blend was examined for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The compressed tablets were evaluated for drug content, friability, disintegration time in - vitro , wetting time and dissolution rate. The flowability tests and the q uality control tests for tablets were done and good results were obtained for all formulae. In vitro dissolution studies showed the releas e in the following descending order of superdisintegrants: Crospovidone > Croscarmellose s odium > Sodium Starch Glycolate . S election of the best formula was done and it was found that F6 the formula which contains Crosspovidone 5 mg showed the fastest disi ntegration time in 16 seconds and drug release about 100 % in 8 minutes. The accelerated stability study was done for formula F6 . It was concluded that Crosspovidone at a concentration of 5 mg is suitable for preparing rapid disintegrating tablet s of Chlor ophenoxamine hydrochloride.