Abstract
Montelukastsodium is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. In addition, patients with asthma need fast and immediate action of drug and avoidance of water is also desirable. Further, chewable tablets are beneficial for patients having difficulty in swallowing. The objective of the present study was to develop chewable tablets containing different compositions of ingredients by using direct compression method. Microcrystalline cellulose, mannitol, magnesium stearate, cross povidone and aspartame were used in the formulation in different concentrations. The prepared tablets were evaluated for various parameters like weight variation, thickness, friability, drug content, and in-vitro drug release. The in-vitro release study of formulation F7 was found to show 98% drug release in 30 minutes and stability studies showed no significant changes.
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