Abstract
The aim of the study was to formulate and evaluate Losartan potassium buccal films, an angiotensin receptor blocker and is used to treat hypertension. Losartan potassium is having less bioavailability (33%), so the buccal films are expected to increase the bioavailability by avoiding hepatic metabolism. Ten formulations of buccal films were prepared by solvent casting method using HPMC K15 M as the main film-forming polymer in various proportions with various co-polymers such as Eudragit RL. 100, Carbopol 940, Ethyl cellulose. Physicochemical characteristics,in vitro buccal permeation, in vitro release study and residence time were evaluated. In vitro studies revealed that the release rate of Losartan potassium was higher for films containing HPMC K15 M and Eudragit RL100 in 3:1 ratio. The result of stability study indicated that no significant changes have occurredduring the period of study.
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