Formulation and evaluation of Boswellia serrata resin gel by using different gelling agents

Abstract

The main objective of the present research work was to develop herbal gel of Boswellia serrata (Shallaki gum) for Antiarthritic activity to achieve greater therapeutic effect. Rheumatoid arthritis is a chronic, metabolic disorder which affects joints and periarticular tissue. The plant Shallaki is the best traditional medicine for the treatment of rheumatoid arthritis. The motive of this work is to formulate an effective formulation for the treatment of rheumatoid arthritis without any side effect as seen in synthetic drugs because the use of synthetic NSAID’S creates problem-related to the gastrointestinal tract which may further complicate the situation. Hence there is a need to use in Herbal formulation, Shallaki is very effective in osteoarthritis, juvenile in rheumatoid arthritis, soft tissue fibrolite, and spondylitis without any side effect. The Boswellia serrata (Shallaki) resin gel by using a different gelling agent like Carbopol, HPMC K4M, and Pluronic F127 gives a better therapeutic result. All the formulations (F1 to F8) were subjected for evaluations like physical appearance; pH was found to be 6.09%, in-vitro drug release study was found to be 90.66% at 8 hrs, viscosity was found to be 66800cp, spreadability was found to be 22.12gm\sec. FTIR results showed no interaction between drug and polymers. Boswellia serrata is one specific Ayurvedic remedy that was proceeded to extract the gum resin for the treatment of rheumatoid arthritis. The benefits of Boswellia are relatively well explained the focus mostly to reduce the inflammation or pain caused due to rheumatoid arthritis. Formulation (F5) shows the best result of drug release 90.66% at 8 hrs which containing 0.2% Carbopol and 4% Pluronic F127 as a gelling agent.