Abstract
The objective of the present investigation was to explore the hydrogel microspheres loaded with Ofloxacin to obtain controlled release for ocular delivery. The FTIR spectra of pure drug and the drug excipient mixture revealed no chemical interaction. Ofloxacin loaded hydrogel microspheres were prepared using Chitosan/Pluronic F127 blend and emulsion crosslinking method. F7 with blend ratio 3.33:1 exhibited the highest encapsulation efficiency (77.85%) whereas the lowest encapsulation was witnesses in the formulation F3 (32.10%) which has a blend ratio of 15:1. The particle size ranged from 29.3 µm for F3 to 146.5 µm for F7. The microspheres exhibited negative zeta potential and the value was found to be -17.5mV for F7. F3 exhibited the highest water uptake (316.0 %) whereas F7 exhibited the lowest water uptake (81.0 %). F7 released around 58.4% drug after 24 h. Hence F7 was considered to be the most optimized formulation. The release of Ofloxacin from F7 followed Higuchi mathematical model suggesting Non-Fickian diffusion.
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