Formulation and Evaluation of Bilayer Tablets of Glimepiride and Metformin HCL

Abstract

The objective of the present investigation was to prepare bilayer tablets of Glimepride and Metformin HCL in combination. Metformin hydrochloride and Glimepiride are oral hypoglycemic drug and effectively used in treatment of diabetes mellitus (type-2 diabetes). The main aim of the present study was to formulate Metformin hydrochloride sustained release and Glimepride immediate release matrix tablets as a dosage form by different polymers such as HPMC, Povidone, Lactose Monohydrate, Ethylcellulose, Microcrystalline Cellulose and study the invitro release patterns of the drug. In the present study bilayer tablets Glimepride prepared by direct compression method and Metformin prepared by wet granulation technology. The prepared tablets were evaluated for various physicochemical parameters such as drug-excipient interaction by FTIR,flow properties, hardness, weight variation, friability, and in vitro dissolution studies optimised based on desired sustained release time (16hrs) and acceptable floating properties The FTIR study revealed that there is no drug-excipient interaction. During preformulation it has been observed that there is no drug- drug and drug excipient interaction, so the excipients which have been selected for the formulation are compatible with the drugs. This system provides zero order or near zero order release for IR layer and SR layer provides Higuchi model.