Abstract
ObjectiveTo develop topical gel formulations of Psoralen using natural excipients to minimize the side effects of synthetic drugs. MethodsThe Psoralen gel formulations were prepared using different natural gums and polymers. The physicochemical compatibility between Psoralen and other excipients was confirmed by using Fourier transform infrared spectroscopy. All prepared gel formulations were evaluated for drug content uniformity, viscosity, pH, and stability. The release of psoralen from all formulations using dialysis membrane into a phosphate buffer pH 6.8 at 37°C was studied. Drug release from the formulations fitted best to the Higuchi model. From the drug release data the best formulation was optimized and the biological studies on albino mice were performed. ResultsPsoralen gel containing egg albumin and xanthan gum shows better incorporation of the drug. The drug activity was found to be 43.3%. Anti-psoriatic drug enhances the orthokeratotic cell differentiation in the epidermal scales. ConclusionsIn vitro anti-psoriatic activity of F3 showed the significant orthokeratosis in the mouse tail test when compared to control thus indicating that the formulation is effective in treating psoriasis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
